The study investigated the effects of 5E-Learning Model on Creativity, Performance and Retention in Ecology among Secondary School II Students in Zaria Education Zone, Kaduna Nigeria. The research design adopted for the study was quasi experimental design pretest-posttest, post-posttest control group. The population was 5180 of co-education students from nineteen schools.Six schools were ramdomly selected and pretested out of which two schools of equivalent classes purposively sampled 100 students was drawn. The instruments were Biology Achievement Test (BAT) and Creativity Assessment Scale (CAS) which were validated byexperts. The reliability coefficients were 0.86 and 0.85for BAT and CAS respectively. The treatment was for six (6)weeks. Six Research Questions and sixnull Hypotheses guided the study.Research Questions were answered using descriptive statistics mean and Standard Deviation on students performance using 5Elearning model and lecture method among others.The null Hypotheses were tested using ttest at significant level of P≤0.05 among others. The result shows there was no significant difference in performance of students taught Ecology concepts using 5E-Learning Model based on gender.In testing the hypotheses on performance, t-test,2-way MANOVA multiple analyses at P≤0.05 were used. Mann Whiney test was used for creativity among others.The findings of the study showed that experimental group performed significantly better than those exposed to lecture method.This shows that, 5E-Learning model of instructionwas favorable to students of ecology concept.Recommendationmade thatteachers teachingEcology concept to students should be encouragedto use5E-Learning model of instruction in teaching at SeniorSecondary Schools among others