The purpose of this study was to assess the knowledge and attitude of teachers towards safety and security of secondary school students in Northern states of Nigeria. An ex-post facto research design was used to study 384 subjects drawn from six states of Northern Nigeria. A multistage sampling procedure was used to draw the required sample. A self-developed questionnaire titled questionnaire on assessment of knowledge and attitude of teachers towards safety and security of secondary school students in Northern states of Nigeria was used to obtain information from the respondents. The questionnaire was divided into four sections, A-D. Section A sought information on the demographic variable of the respondent; section B1 deals with knowledge on safety; section B2 deals with attitude towards safety; section C1deals with knowledge on security; section C2 sought information on attitude towards security; section D1 deals with the availability of safety measures and section D2 deals with the information on availability of security measures. Data collected were analysed using mean and standard deviation, t-test and one-wayanalysis of variance (ANOVA) statistics. Six research questions were asked and six hypotheses were tested at 0.05 level of significance. Findings showed that, teachers have adequate knowledge on safety of secondary school students in northern states of Nigeria; the attitude of teachers towards safety of secondary school students in northern states of Nigeria is positive. Based on the findings of this study, the following conclusions were drawn,teachers in Northern states of Nigeria have adequate knowledge on safety of Secondary school students; Teachers in Northern states of Nigeria have positive attitude towards safety of secondary school students. On the basis of the findings of this study, the following recommendations were made; seminars, conferences and workshops should be organized for teachers in order to update their knowledge on safety and security which will reflect in their attitude; The school management should take the issue of school security as a matter of priority and so allocate money for the purchasing of such safety and security building equipment such as video surveillance (CCTV), sprinkler system to control fire damage, metal detectors, iron doors, employ armed response services and secured parking.