The work was on influence of National Open Apprenticeship Scheme (NOAS) on youths? empowerment in North-east Geo-political Zone, Nigeria. The study has four specific objectives. This study has four research questions which were intended to direct the study. Four null hypotheses were formulated and tested at 0.05 level of significance. The study adopted the descriptive survey design. The population was 6,453 NOAS graduates located in the North-east Geo-political zone of Nigeria, and the sample size was 377, which were selected using the Cluster sampling method. Questionnaire and fixed response interview were used to collect data; the data collection process lasted for 14 days. The demographic data were analyzed using percentages. The research questions were answered using mean and standard deviation. The hypotheses were tested using simple regression at 0.05 level of significance. The four null hypotheses were rejected. One of the major findings is that the National Open Apprenticeship Scheme training influenced youths? acquisition of employable skills. The study concluded that the National Open Apprenticeship Scheme empowered youths in the North-east Geo-political zone of Nigeria. Four recommendations were made, one among which is: The Federal Government of Nigeria should put in more efforts to sustain the National Open Apprenticeship Scheme programme by constantly reviewing its progress and providing essential human and material resources to the training outlets